房新强，男，理学博士，研究员、课题组长、博士生导师。籍贯山东淄博。2005年硕士毕业于中国科学技术大学（指导教师：刘有成院士），2009年博士毕业于中国科学院上海有机化学研究所（指导教师：李超忠研究员）；2009-2013年从事博士后研究，2013年9,引进到中国科学院福建物质结构研究所工作，任研究员，课题组长。研究方向：有机合成方法学，不对称催化、新型催化剂和配体的设计合成及其应用、天然产物和药物活性分子的合成

招生专业：有机化学

电子邮件：xqfang@fjirsm.ac.cn

联系电话： 0591-63173513

办公室地址：海西院新区1号楼1313

课题组介绍：http://www.fjirsm.cas.cn/fangxinqiang/

    课题组位于海西院新区，依托结构化学国家重点实验室和煤制乙二醇及相关技术中科院重点实验室开展工作。课题组拥有充裕的实验室面积和齐全的各类仪器设备。课题组成员共同组成了一支包含硕士/博士/博士后/副研究员/研究员的拼搏向上的科研队伍；课题组制定了多种奖励措施鼓励勤奋进取的学生，并与国内外多个知名课题组建立了广泛的交流合作，为有志于进一步深造的优秀学生提供良好的支持。欢迎热爱有机化学的优秀人才加入我们课题组，锐意进取，共攀高峰！

研究成果：

40. Organocatalyzed Kinetic Resolution of a-Functionalized Ketones: the Malonate Unit Leads the Way, Jian Liu, Laxmaiah Vasamsetty, Muhammad Anwar, Shuang Yang,* Weici Xu,  Jinggong Liu, Sakkani Nagaraju, and Xinqiang Fang,* ACS Catal. 2020, 10, 2882-2893.

39. Regioselectivity-Switchable Catalytic Annulations of Alkynyl α-Diketones and α-Cyanoketones, Sakkani Nagaraju, Shuhua Liu, Jinggong Liu, Shuang Yang, Rui Liu, Zhizhou Chen, Banoth Paplal,and Xinqiang Fang,* Org. Lett. 2019, 21, 10075-10080.

38. Stereodivergent Access to Enantioenriched Epoxy Alcohols with Three Stereogenic Centers via Ruthenium-Catalyzed Transfer Hydrogenation, Zhifei Zhao, Prasanta Ray Bagdi, Shuang Yang, Jinggong Liu, Weici Xu,* and Xinqiang Fang,* Org. Lett. 2019, 21, 5491-5494.

37. Asymmetric Synthesis of Dihydronaphthalene-1,4-diones via Carbene-Catalyzed Stereodivergent Reaction, Zhifei Zhao, Shuang Yang, Shouang Lan, Jinggong Liu, Shuhua Liu,* and Xinqiang Fang,* Adv. Synth. Catal. 2019, 361, 3943-3949.

36. Carbene-Catalyzed Asymmetric Friedel-Crafts Alkylation-Annulation Sequence and Rapid Synthesis of Indole-Fused Polycyclic Alkaloids, Muhammad Anwar, Shuang Yang, Weici Xu, Jinggong Liu, Saima Perveen, Xiangwen Kong, Syeda Tazeen Zehra, and Xinqiang Fang,* Communications Chemistry 2019, 2: 85.

35. Bifunctional Thiourea-Catalyzed Asymmetric Inverse-Electron-Demand Diels-Alder Reaction of Allyl Ketones and Vinyl 1,2-Diketones via Dienolate Intermediate, Xinglong Li, Xiangwen Kong, Shuang Yang,* Miao Meng, Xinyue Zhan, Min Zeng, and Xinqiang Fang,* Org. Lett. 2019, 21, 1979-1983.

34. Kinetic Resolution of b-Ketoesters with Quaternary Stereocenters via Carbene-Catalyzed Benzoin Reaction, Syeda Tazeen Zehra, Guoxiang Zhang, Shuang Yang, and Xinqiang Fang,* Org. Biomol. Chem. 2019, 17, 2169-2173.

33. Asymmetric Total Synthesis of Rotenoids via Organocatalyzed Dynamic Kinetic Resolution, Saima Perveen, Shuang Yang, Miao Meng, Weici Xu, Guoxiang Zhang, and Xinqiang Fang,* Communications Chemistry 2019, 2:8. DOI: 10.1038/s42004-019-0110-y.

32. Kinetic Resolution of 2,2-Disubstituted-1,3-Diketones via Carbene Catalysis, Weici Xu, Yuanzhen Li, Rui Liu, Shuang Yang, Jian Liu, and Xinqiang Fang,* Org. Chem. Front. 2019, 6, 290-298.

31. Divergent Dynamic Kinetic Resolution of Racemic Mixture of Four Stereoisomers via N-Heterocyclic Carbene Organocatalysis, Laxmaiah Vasamsetty, Xiangwen Kong, Miao Meng, Shuang Yang, Weici Xu, Pogula Sreekanth Reddy, and Xinqiang Fang,* Chem. Asian J. 2018, 13, 3838-3844.

30. Cyclopentadienone Formation from β,γ-Unsaturated Cyclopentenones and Its Application in Diels–Alder Reactions, Xiangwen Kong, Shuang Yang, Fang Yu, Laxmaiah Vasamsetty, Jian Liu, Shuhua Liu,* Xiaozhi Liu,* andXinqiang Fang,* J. Org. Chem. 2018, 83, 8953-8961.

29. Br？nsted Base-Catalyzed Annulation of Allyl Ketones and Alkynyl 1,2-Diketones, Xiangwen Kong, Jinshuai Song, Jian Liu, Miao Meng, Shuang Yang, Min Zeng, Xinyue Zhan, Chunsen Li,* and Xinqiang Fang,* Chem. Commun. 2018, 54, 4266-4269. 

28. N-Heterocyclic Carbene-Catalyzed Umpolung of β,γ-Unsaturated 1,2-Diketones, Jian Liu, Deb Kumar Das, Guoxiang Zhang, Shuang Yang, Hao Zhang, and Xinqiang Fang,^* Org. Lett. 2018, 20, 64-67. 

27. Enantioselective intermolecular all-carbon [4+2] annulation via N-heterocyclic Carbene organocatalysis, Guoxiang Zhang, Weici Xu, Jian Liu, Deb Kumar Das, Shuang Yang, Saima Perveen, Hao Zhang, Xinglong Li and Xinqiang Fang,* Chem. Commun. 2017, 53, 13336-13339.

26. Book Chapter, Nonnitrogenous Organocatalysis, Andrew M. Harned, Ed. Chartper 7, Page 151-183, N-Heterocyclic Carbene Catalysis: Homoenolate and Enolate Reactivity, Xinqiang Fang,* and Yonggui Robin Chi,* CRC Press, Taylor & Francis Group, Dec-15, 2017. ISBN 9781498715034

25. N-Heterocyclic Carbene-Catalyzed Umpolung of Alkynyl 1,2-Diketones, Xiangwen Kong, Guoxiang Zhang, Shuang Yang, Xiaozhi Liu, and Xinqiang Fang,* Adv. Synth. Catal. 2017, 359, 2729-2734.

24. Enantioselective Synthesis of 1,2-Dihydronaphthalenes via Oxidative N-Heterocyclic Carbene Catalysis, Saima Perveen, Zhifei Zhao, Guoxiang Zhang, Jian Liu, Muhammad Anwar, and Xinqiang Fang,* Org. Lett. 2017, 19, 2470-2473.

23. Kinetic Resolutions Enabled by N-Heterocyclic Carbene Catalysis, Shuang Yang, Xinqiang Fang,* Curr. Org. Syn. 2017, 14, 654. (review paper)

22. A Genetically Encoded Allysine for the Synthesis of Proteins with Site-Specific Lysine Dimethylation, Zhipeng A. Wang, Yu Zeng, Yadagiri Kurra, Xin Wang, Jeffery M. Tharp, Erol C. Vatansever, Willie W. Hsu, Susie Dai, Xinqiang Fang,* and Wenshe R. Liu,* Angew. Chem., Int. Ed. 2017, 56, 212-216. 

21. Stereodivergent Synthesis of Chromanones and Flavanones via Intramolecular Benzoin Reaction, Genfa Wen, Yingpeng Su, Guoxiang Zhang, Qiqiao Lin, Yujin Zhu, Qianqian Zhang, and Xinqiang Fang,* Org. Lett. 2016, 18, 3980-3983.

20. Dynamic Kinetic Resolution Enabled by Intramolecular Benzoin Reaction: Synthetic Applications and Mechanistic Insights, Guoxiang Zhang, Shuang Yang, Xiaoyan Zhang, Qiqiao Lin, Deb K. Das, Jian Liu, and Xinqiang Fang,* J. Am. Chem. Soc. 2016, 138, 7932-7938. (Highlighted by Synfacts 2016, 972)

19. N-Heterocyclic Carbene-catalyzed Desymmetrization of Functionalized 1,4-Dienes via Stetter Reaction, Qiqiao Lin, Yuanzhen Li, Deb Kumar Das, Guoxiang Zhang, Zhifei Zhao, Shuang Yang* and Xinqiang Fang,* Chem. Commun. 2016, 52, 6459-6462.

18. Asymmetric Desymmetrization of 1,3-Diketones via Intramolecular Benzoin Reaction, Yuanzhen Li, Shuang Yang, Genfa Wen, Qiqiao Lin, Guoxiang Zhang, Lin Qiu, Xiaoyan Zhang, Guangfen Du,* Xinqiang Fang,* J. Org. Chem. 2016, 81, 2763-2769.

Before Independence:

17. Stereoselectivity of 6-Exo Cyclization of α-Carbamoyl Radicals, Song, L.; Fang, X.; Wang, Z.; Liu, K.; Li, C.* J. Org. Chem. 2016, 81, 2442-2450.

16. The Genetic Incorporation of Thirteen Novel non-Canonical Amino Acids. Tuley, A.; Wang, Y.-S.; Fang, X.; Kurra, Y.; Rezenom, Y. H.; Liu, W. R.* Chem. Comm. 2014, 50, 2673-2675.

15 Fang, X.^？; Fu, Y.^？; Long, M. C.; Haegele, J. A.; Ge, E. J.; Parvez, S.; Aye, Y.* Temporally Controlled Targeting of 4-Hydroxynonenal to Specific Proteins in Living Cells. J. Am. Chem. Soc. 2013, 135, 14496-14499. (^？ contributed equally).

14. Sun, H.; Fang, X.; Chi, Y. R.*; Li, G.* Theoretical Study of N-Heterocyclic Carbenes-Catalyzed Cascade Annulation of Benzodienones and Enals. Chirality 2013, 25, 521-528.

13. Lee, Y.-J. C.; Wu, B.; Raymond, J. E.; Zeng, Y.; Fang, X.; Wooley, K. L.; Liu, W. R.* A Genetically Encoded Acrylamide Functionality. ACS Chem. Biol. 2013, 8 ,1664-1670.

12. Chen, X.^？; Fang, X.^？; Chi, Y. R.* Cis-Enals in N-Heterocyclic Carbene-Catalyzed Reactions: Distinct Stereo-Selectivity and Reactivity. Chem. Sci. 2013, 4, 2613-2618. (^？ contributed equally) 

11. Wang, Y.-S.^？; Fang, X.^？; Chen, H.-Y.; Wu, B.; Wang, Z. U.; Hilty, C.; Liu, W. R.* Genetic Incorporation of Twelve meta-Substituted Phenylalanine Derivatives Using a Single Pyrrolysyl-tRNA Synthetase Mutant. ACS Chem. Biol. 2013, 8, 405-415. (^？ contributed equally)

10. Wang, Y.-S.; Fang, X.; Wallace, A. L.; Wu, B.; Liu, W. R.* A Rationally Designed Pyrrolysyl-tRNA Synthetase Mutant with a Broad Substrate Spectrum. J. Am. Chem. Soc. 2012, 134, 2950-2953.

9. Fang, X.; Chen, X.; Lv, H.; Chi, Y. R.* Enantioselective Stetter Reactions of Enals and Modified Chalcones Catalyzed by N-Heterocyclic Carbene. Angew. Chem. Int. Ed. 2011, 50, 11782-11785.

8. Lv, H.; Mo, J.; Fang, X.; Chi, Y. R.* Formal Diels-Alder Reactions of Chalcones and Formylcyclopropanes Catalyzed by Chiral N-Heterocyclic Carbenes. Org. Lett. 2011, 13, 5366-5369.

7. Fang, X.; Chen, X.; Chi, Y. R.* Enantioselective Diels-Alder Reactions of Enals and Alkylidene Diketones Catalyzed by N-Heterocyclic Carbenes. Org. Lett. 2011, 13, 4708-4711.

6. Fang, X.; Jiang, K.; Xing, C.; Hao, L.; Chi, Y. R.* A Highly Regio- and Stereoselective Cascade Annulation of Enals and Benzodi(enone)s Catalyzed by N-Heterocyclic Carbenes. Angew. Chem. Int. Ed. 2011, 50, 1910-1913.

5. Fang, X.; Liu, K.; Li, C.* Efficient Regio- and Stereoselective Formation of Azocan-2-ones via 8-Endo Cyclization of α-Carbamoyl Radicals. J. Am. Chem. Soc. 2010, 132, 2274-2283.

4. Fang, X.; Xu, H.-J.; Jiang, H.; Liu, Y.-C.*; Fu, Y.; Wu, Y.-D.* A Study on the Reactions of NADH Models with Electron Deficient Alkenes. A Probe for the Extreme of Concerted Electron-hydrogen Atom Transfer Mechanism. Tetrahedron Lett. 2009, 50, 312-315.

3. Pan, Y.; Lu, H.; Fang, Y.; Fang, X.; Chen, L.; Qian, J.; Wang, J.; Li, C.* Synthesis of Pyrroles via Copper-Catalyzed Coupling of Amines with Bromoenones. Synthesis 2007, 1242-1246.

2. Fang, X.; Liu, Y.-C.*; Li, C.* 9-Phenyl-10-methylacridinium: A Highly Efficient and Reusable Organocatalyst for Mild Aromatization of 1,4-Dihydropyridines by Molecular Oxygen. J. Org. Chem. 2007, 72, 8608-8610.

1. Fang, X.; Liu, Y.-C.*; Wang, G.-W.; Ke, Y.-P. A Novel Coenzyme NADH Model 1-Benzyl-1,4-dihydronicotinamide-mediated Reaction: A Single Intermediate Serves two Mechanisms. Res. Chem. Intermediat. 2006, 32, 603-611.